Controlled release succinic acid microcapsules coated with aqueo

Details Controlled release succinic acid microcapsules coated with aqueo Controlled release succinic acid microcapsules coated with aqueo

1992-04-13

1995-03-07

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424468, 424474, 424487, A61K 950

Patent

active

053956281

ABSTRACT:
A controlled release pharmaceutical preparation comprising (a) a core containing a pharmaceutically active substance and an organic acid, and (b) a coating film formed on the surface of the core by aqueous coating of a water-insoluble and water-slightly permeable acrylic polymer containing a trimethylammonium-ethyl group, which exhibits well controlled dissolution and release of the pharmaceutically active substance when administered and can maintain the desired blood level of the active substance for a long period of time, and a method for producing the preparation.

REFERENCES:
patent: 4427648 (1984-01-01), Brickl et al.
patent: 4737357 (1988-04-01), Lehmann et al.
patent: 4820521 (1989-04-01), Panoz et al.
patent: 4940588 (1990-07-01), Sparks et al.
Documentation from Rohm Pharma, "EUDRAGIT.RTM. RL/RS-Dispersionen"; Vorlaufiges Merkblatt.
Documentation from Rohm Pharma GmbH Co., "Eudragit RL30D and RS30D: Aqueous Acrylic Resin Dispersion-Application in the Production of Pharmaceutical Preparations", Prospectus (Infor RL/RSD-1/e), pp. 1-7.
R. S. Okor, W. Anderson, "Communications: Casting solvent effects on the permeability of polymer films of differing quaternary ammonium (cation) content", J. Pharm. Pharmacol, (1987) 39, pp. 547-548.

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