Controlled release solid drug dosage forms based on mixtures of

Details Controlled release solid drug dosage forms based on mixtures of Controlled release solid drug dosage forms based on mixtures of

1984-03-26

1989-01-03

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, 424494, A61K 922

Patent

active

047953276

ABSTRACT:
A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a controlled and prolonged release pattern upon administration, the carrier base material being a mixture of one or more nonionic cellulose ethers and an anionic surfactant, and wherein at least one of the cellulose ethers is methyl cellulose or hydroxypropylmethylcellulose having a number average molecular weight of at least 50,000.

REFERENCES:
patent: 4138475 (1979-02-01), McAinish et al.
patent: 4155993 (1979-05-01), Belleville et al.
patent: 4259314 (1981-03-01), Lowey
patent: 4369172 (1983-01-01), Schor et al.
patent: 4389393 (1983-06-01), Schor et al.
patent: 4404183 (1983-09-01), Kawata et al.
Daly "Effect of Anionic Surfactants on the Release of Chlorpheniramnine from a Polymer Matrix Tablet" Int. J. Pharm. 18 (1984) 201-205.

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