Controlled-release preparations

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424451, 424456, 514962, A61K 948

Patent

active

056373198

ABSTRACT:
The invention provides oral controlled-release preparations suitable to deliver drugs to different sites of gastrointestinal tract and suitable to control the release rate of drugs. As a first function, targeting of drugs to the lower part of the small intestine or colon is possible with two technologies. One is a time-controlled release system comprising adjusting the balance of the tolerability and thickness of a water-insoluble material membrane and the amount of a swellable substance. The other one is an intestinal pressure controlled-release system comprising adjusting the thickness of a water-insoluble material membrane. As a second function, by adjusting pore number, pore size and the amount of gel-forming substance, a sustained-release preparation of extremely water-soluble, hydrophilic, low-molecular weight drug is possible.

REFERENCES:
patent: 4496553 (1985-01-01), Halskov
patent: 4816264 (1989-03-01), Phillips et al.
patent: 4980173 (1990-12-01), Halskov
patent: 5217720 (1993-06-01), Sekigawa et al.
patent: 5273760 (1993-12-01), Oshlack et al.
patent: 5283064 (1994-02-01), Suzuki et al.
patent: 5424289 (1995-06-01), Yang et al.
patent: 5541170 (1996-07-01), Rhodes et al.
patent: 5541171 (1996-07-01), Rhodes et al.
Christensen, L.A., et al, Aliment. Pharmacol. Therap. 4, 523-533 (1990).
Dew, M.J., et al, Br. J. Clin. Pharmac., 14, 405-408 (1982).
Laursen, L.S., et al, Gvt 31, 1271-1276 (1990).
Lehman, K., Manufacturing Chemist & Aerosol News, pp. 39-41 Jun. 1973.
Stolk, L.M.L., et al, Pharmaceuti. Sch. Weekblad Scientific edition, 12(5), 200-204 (1990).
Rohm Pharma Brochure titled "Eudragit.RTM." Lacquers for Tablet Coating, pp. 1-29, 1973.
Rohm Pharma Brochure titled "Eudragit.TM. L and S", pp. 3-4, 1973.
Niwa, K., et al, "Colon Delivery Technics for Oral Administration of Recombinant protein drugs (1), Development of Time Controlled-Release Colon Delivery System", The 114 Annual Meeting of Japan Pharmaceutical Society, Abstracts, 98, Mar. 5, 1994.
Takada, K., et al, "Colon Delivery Technics, Time Controlled-Release Colon Delivery Capsules" (Abstract), Drugs Delivery System, vol. 9, No. 4, 272, Jul. 10, 1994.
Takaya, T., et al, "Usefulness of Colon Delivery System for Oral Administration of Recombinant Protein Drugs" (Abstract), The Seventh Japanese-American Conference on Pharmacokinetics and Biopharmaceutics, Hiroshima, Japan, Jul. 31-Aug. 2, 1994.
Takaya, T., et al, "Colon Delivery Technics for Oral Administration of Recombinant protein drugs (2), Assessment of Oral rhG-CSF Preparation Using Colon Delivery System in Beagle Dogs", The 114th Annual Meeting of Japan Pharmaceutical Society, Abstracts, 98, Mar. 5, 1994.
Takaya, T., et al, "Colon Delivery Technics, Colon Delivery Capsules Using Gastrointestinal Pressure" (Abstract), Drugs Delivery System, vol. 9, No. 4, 273, Jul. 10, 1994.
Takada, K., et al, "Systematic Availability of 5-ASA after Oral Administration to Beagle Dogs with Colon Delivery Capsule" (Abstract), International Symposium on Recent Advances in Inflammatory Bowel Disease, Nara, Japan, Nov. 23-24, 1994.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Controlled-release preparations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Controlled-release preparations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled-release preparations will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-763035

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.