Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1995-03-01
1997-06-10
Bleutge, John C.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424451, 424456, 514962, A61K 948
Patent
active
056373198
ABSTRACT:
The invention provides oral controlled-release preparations suitable to deliver drugs to different sites of gastrointestinal tract and suitable to control the release rate of drugs. As a first function, targeting of drugs to the lower part of the small intestine or colon is possible with two technologies. One is a time-controlled release system comprising adjusting the balance of the tolerability and thickness of a water-insoluble material membrane and the amount of a swellable substance. The other one is an intestinal pressure controlled-release system comprising adjusting the thickness of a water-insoluble material membrane. As a second function, by adjusting pore number, pore size and the amount of gel-forming substance, a sustained-release preparation of extremely water-soluble, hydrophilic, low-molecular weight drug is possible.
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Bleutge John C.
Harrison Robert H.
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