Controlled release preparation for administering morphine

Details Controlled release preparation for administering morphine Controlled release preparation for administering morphine

1997-04-21

1999-09-14

Bawa, Raj

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 424457, 424459, 424463, 424474, 424475, 424489, A61K 954

Patent

active

059520051

ABSTRACT:
An oral pharmaceutical preparation containing a therapeutically effective amount of a salt of morphine for administration once daily is provided. The preparation contains particles which have a core containing a salt of morphine coated with a barrier layer. The barrier layer is formed from a coating liquid that contains at least one water insoluble barrier forming component selected from the group consisting of ethyl cellulose, copolymers of acrylic and methacrylic esters and natural or synthetic waxes, and a plasticizer. The mean serum concentration of morphine obtained is at least 50% of the maximum serum concentration during at least 12 hours after the administration of a single dose of the preparation.

REFERENCES:
patent: 4557925 (1985-12-01), Lindahl et al.
Olsson et al. (1991). Proc. Int. Symp. Cont. Rel. Biact. Mater., vol. 18, pp. 433-434.
Gennaro, A.R. (1985). Remington's Pharmaceutical Sciences. Mack Pub. Co., pp. 1610-1615, 1621.

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