Controlled release preparation

Details Controlled release preparation Controlled release preparation

1994-03-16

1997-03-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424457, 424458, 424459, 424463, 424474, 424475, 424489, A61K 948

Patent

active

056142188

ABSTRACT:
An oral controlled release pharmaceutical preparation in the form of a tablet, capsule or sachet containing a plurality of coated particles comprising a therapeutically effective amount of a salt of morphine coated with a barrier membrane providing a controlled, preferably pH-independent, release of morphine in that the serum concentration of morphine obtained is at least 50% of the maximum serum concentration during at least 12 hours after administration of a single dose, and providing a significantly reduced plasma concentration fluctuation compared to known morphine preparations. A method for the manufacture of such a preparation and the use of such preparations for the manufacture of an analgesic useful in the treatment of severe chronicle pain are also provided.

REFERENCES:
Hardy, Colonic Transit and Drug Delivery, Drug Delivery to the Gastrointestinal Tract, Ellis Horwood Limited, Halsted Press, pp. 75-81.
Olsson, et al., Bioavailability and Gastro-Intestinal Transit of Two Morphine CR Tablets, Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 18(1991), Controlled Release Society, Inc., pp. 433-434.

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