Controlled release preparation

Details Controlled release preparation Controlled release preparation

1995-04-21

1997-08-12

Bawa, Raj

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 424457, 424459, 424463, 424474, 424475, 424489, A61K 954

Patent

active

056562918

ABSTRACT:
A method for manufacturing an oral controlled release pharmaceutical preparation in the form of a capsule containing a plurality of coated particles comprising a therapeutically effective amount of a salt of morphine coated with a barrier membrane providing a controlled, preferably pH-independent, release of morphine in that the serum concentration of morphine obtained is at least 50% of the maximum serum concentration during at least 12 hours after administration of a single dose, comprising spray coating the morphine containing particles with a coating liquid and drying.

REFERENCES:
patent: 4557925 (1985-12-01), Lindahl et al.
Olsson et al. (1991). Proc. Int. Symp. Cont. Rel. Biact. Mater., vol. 18, pp. 433-434.
Gennaro, A. R. (1985). Remmington's Pharmaceutical Sciences. Mack Pub. Co., pp. 1610-1615, 1621.

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