Controlled release potassium dosage form

Details Controlled release potassium dosage form Controlled release potassium dosage form

1993-10-04

1995-03-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424457, 424458, 424462, 424463, 424456, A61K 962

Patent

active

053975740

ABSTRACT:
A pharmaceutical composition for oral administration of potassium salt in a form not irritating to the gastrointestinal mucosa comprises tablets or capsules of micropellets of a potassium salt, such as potassium chloride. The micropellets are coated with a permeable polymer comprising a low viscosity (10 cp.) ethylcellulose in combination with triacetin. This coating provides a strong film resistant to breakage during formation of tablets and filling of capsules. The protective coating of the micropellets prevents the early release of potassium ions, while the tablet or capsule disintegrates and the micropellets are dispersed within the lumen of the gastrointestinal tract. As water passes through the permeable but insoluble coating, potassium ions are gradually eluted into the fluid of the tract over a period of many hours, thereby allowing time for the ions to be absorbed from the tract before high, irritating ion concentrations can form.

REFERENCES:
patent: 4798724 (1989-01-01), Khanna
patent: 4863743 (1989-09-01), Hsiao
patent: 4946685 (1990-08-01), Edgren et al.
patent: 5035898 (1991-07-01), Chang
patent: 5200195 (1993-04-01), Dong et al.
patent: 5260069 (1993-11-01), Chen
Baum et al. Total Body Exchangeable Potassium . . . American Heart Journal 58(2) Jul. 1959 (53-58).

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