Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1986-02-19
1989-09-05
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424480, 424482, 424495, 424497, 424498, A61K 932, A61K 936
Patent
active
048637432
ABSTRACT:
A controlled release potassium chloride tablet is disclosed which is comprised of potassium chloride crystals having a mesh size of about 30 to about 50 mesh which are coated with a coating material comprised of ethylcellulose and hydroxypropylcellulose. The coated crystals form micro pellets which then can be compressed into tablets. The tablets disintegrate rapidly in an aqueous environment thus assuring a more uniform dissolution of the active component as compared with other types of controlled release potassium chloride dosage formulations. The distribution of the potassium chloride micro pellets over a wide surface area in the gastrointestinal mucosa aids in reducing the risk of gastrointestinal lesions. The formation of the coated micro pellets which disperse quickly upon contact with aqueous environment allow for the repeated chronic oral administration of a relatively large dose of potassium chloride (20 mEq).
REFERENCES:
patent: 3538214 (1970-11-01), Polli et al.
patent: 4519801 (1985-05-01), Edgren
patent: 4553973 (1985-11-01), Edgren
patent: 4555399 (1985-11-01), Hsiao
patent: 4629620 (1986-12-01), Lindahl et al.
patent: 4666703 (1987-05-01), Kopf
Chou Chi T.
Hsiao Charles
Key Pharmaceuticals, Inc.
Maitner John J.
Miller Stephen I.
Nelson James
Rose Shep K.
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