Controlled release polypeptide compositions and methods of treat

Details Controlled release polypeptide compositions and methods of treat Controlled release polypeptide compositions and methods of treat

1996-04-23

2000-03-14

Ulm, John

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

514 2, A61K 916, A01N 3718

Patent

active

060369787

ABSTRACT:
The invention pertains to a controlled release pharmaceutical formulation that has an effective amount of a polypeptide selected from the group consisting of: (a) TNFR, (b) IL-1R, (c) IL-1ra, (d) IL-6R and (e) a monoclonal antibody that is immunoreactive against TNF, IL-6 or IL-1; wherein the polypeptide is encapsulated in alginate. The invention also pertains to methods of treating inflammatory bowel disease by administering the above composition to a patient in need thereof.

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