Controlled release pilocarpine delivery system

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514399, 514400, A61K 31415

Patent

active

056611714

ABSTRACT:
There is disclosed a method for treating a patient suffering from xerostomia, xerophthaimia or excessive intraocular pressure. The method comprises administering to said patient a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount sufficient to maintain a blood serum level of pilocarpine in said patient of from about 5 to about 40 ng/ml, for a period of at least 6 hours. Controlled release unit dosage forms containing pilocarpine are also disclosed.

REFERENCES:
patent: 3640741 (1972-02-01), Etes
patent: 4151270 (1979-04-01), Ream et al.
patent: 4209505 (1980-06-01), Mikhail
patent: 4438100 (1984-03-01), Baslev et al.
patent: 4615697 (1986-10-01), Robinson
patent: 4820506 (1989-04-01), Kleinberg et al.
patent: 4900552 (1990-02-01), Sanvordeker et al.
patent: 4906455 (1990-03-01), Hoerman
patent: 4917674 (1990-04-01), Monlinoff
patent: 4938963 (1990-07-01), Parnell
patent: 4988679 (1991-01-01), Chavkin et al.
Physician's Desk Reference For Ophthamology 16 edition, 1988.
Schuller et al., "Treatment of radiation side effects with oral pilocrpine" J. Surg. Oncol. (1989) 42:272-276.
Severin, "Keratoconjunctivitis sicca" Vet. Clin. North Am. (1973) 3:407-422.
Pavan-Langston, "Potential use of ocular-insert therapy in dry eyes" Int. Opthalmol. Clin. (1973) 13:231-238.
Deshpande et al., "Sustained release ophthalmic formulations of pilocarpine" J. Pharm. Pharmacol. (1988)41:197-200.
Fox et al., "Pilocarpine treatment of salivary gland hypofunction and dry mouth (Xerostimia)" Arch. Intern. Med. (1991) 151:1149-1152.
Fox et al., "Xerostomia: evaluation of a symptom with increasing significance" J. Am. Dent. Assoc. (1985) 110;519-525.
Chencharick et al., "Nutritional consequences of the radiotherapy of head and neck cancer" Cancer (1983) 51:811-815.
Fox, "Systemic therapy of salivary gland hypofunction" J. Dent. Res. (1987) 66:689-692.
Fox, "Management of salivary gland hypofunction an ddry mouth (xerostomia)" Head and Neck Cancer, Fee et al., eds., (1990) pp. 322-324.
LeVeque et al., "A Multicenter, randomized, double-blind, placebo-controlled, dose-titration study of oral pilocarpine for treatment of radiation-induced xerostomia in head and neck cancer patients" J. Clin. Oncol. (1993) 11:1124-1131.
Johnson et al., "Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer" N. Engl. J. Med. (1993) 329:390-395.
Greenspan et al., "Effectiveness of pilocarpine in postradiation xerostomia" Cancer (1987) 59:1123-1125.
Dawes, "The composition of human saliva secreted in response to a gustatory stimulus and to pilocarpine" J. Physiol. (London) (1966) 183:360-368.
Mandel et al., "The effect of pharmacologic agents on salivary secretion and composition. II. Isoproterenol, alpha and beta adrenergic blockers" J. Oral. Ther. Pharmacol. (1968) 4:260-269.
Fox et al., "Pilocarpine for the treatment of xerostomia associated with salivary gland dysfunction" Oral Surg. Oral Med. Oral Pathol. (1986) 61:243-248.
Rhodus et al., "Effects of pilocarpine on salivary flow in patients with Sjogren's syndrome" Oral Surg. Oral Med. Oral Pathol. (1991) 72:545-549.
Greco et al., "Systemic pilocarpine toxicity in the treatment of angle closure glaucoma" Ann. Opthalmol. (1973) 5:57-59.
Kastl, "Inadvertent systemic injection of pilocarpine. Case report" Arch. Opthalmol. (1987) 105:28-29.
Littmann et al., "Severe symptomatic atrioventricular block induced by pilocarpine eye drops" Arch. Intern. Med. (1987) 147:586-587.
Weaver et al., "Pilocarpine disposition amd salivary flow responses following intravenous administration to dogs" Pharm. Res. (1992) 9:1064-1069.
Valdez et al., "Interactions of thje salivary and gastrointestinal systems. II. Effects of salivary gland dysfunction on the gastrointestinal tract" Dig. Dis. (1991) 9:210-218.
Hughes et al., "Oral-pharyngeal dysphagia: A common sequela of salivary gland dysfunction" Dysphagia (1987) 1:173-177.
Caruso et al., "Objective measures of swallowing in patients with primary Sjogren's syndrome" Dysphagia (1989) 4:101-105.
Helm, "Role of saliva in esophageal function and disase" Dysphagia (1989) 4:76-84.
Korsten et al., "Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury" Am. J. Med. (1991) 90:701-706.
Lehr et al., "A surface energy analysis of mucoadhesion: Contact angle measurements on polycarbophil and pig intestinal mucosa in physiologically relevant fluids" Pharm. Res. (1992) 9:70-75.
Abstract of Mamtani et al., "Composition of total costs of administering calcium polycarbophil and psyllium mucilloid in an institutional setting" Clin. Therap. (1990) 12:22-25.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Controlled release pilocarpine delivery system does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Controlled release pilocarpine delivery system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled release pilocarpine delivery system will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1988834

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.