Controlled release peroral compositions of levosimendan

Details Controlled release peroral compositions of levosimendan Controlled release peroral compositions of levosimendan

2006-05-16

2006-05-16

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S464000, C424S451000

Reexamination Certificate

active

07045147

ABSTRACT:
The invention relates to peroral pharmaceutical compositions which release levosimendan in a controlled fashion with reduced occurrence of undesired effects. Levosimendan, or (−)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile, is useful in the treatment of congestive heart failure.

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Sandell et al., “Pharmacokinetics of Levosimendan in Healthy Volunteers and Patients with Congestive Heart Failure,” J. Cardiovascular Pharmacology, vol. 26, Suppl. 1, pp. S57-S62 (1995).
Sundberg et al., “Hemodynamic and Neurohumoral Effects of Levosimendan, a New Calcium Sensitizer, at Rest and During Exercise in Healthy Men,” American Journal of Cardiology, vol. 75, pp. 1061-1066 (1995).

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