Controlled release oxycodone compositions

Details Controlled release oxycodone compositions Controlled release oxycodone compositions

1991-11-27

1993-11-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424469, 424470, 424486, 424487, 424488, 424494, 424496, 424497, 424498, 424501, 424502, 424495, A61K 922, A61K 926

Patent

active

052663310

ABSTRACT:
A solid controlled release, oral dosage form, the dosage form comprising a therapeutically effective amount of oxycodone or a salt thereof in a matrix wherein the dissolution rate in vitro of the dosage form, when measured by the USP Paddle Method of 100 rpm in 900 ml aqueous buffer (pH between 1.6 and 7.2) at 37.degree. C. is between 12.5% and 42.5% (by weight) oxycodone released after 1 hour, between 25% and 55% (by weight) oxycodone released after 2 hours, between 45% and 75% (by weight) oxycodone released after 4 hours and between 55% and 85% (by weight) oxycodone released after 6 hours, the in vitro release rate being independent of pH between pH 1.6 and 7.2 and chosen such that the peak plasma level of oxycodone obtained in vivo occurs between 2 and 4 hours after administration of the dosage form.

REFERENCES:
patent: 4861598 (1989-08-01), Oshlack
patent: 4990341 (1991-02-01), Goldie et al.

Affiliated with

Also associated with

Rating

Controlled release oxycodone compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Controlled release oxycodone compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled release oxycodone compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2093898