Controlled release of nitric oxide and drugs from...

Details Controlled release of nitric oxide and drugs from... Controlled release of nitric oxide and drugs from...

2009-07-24

2011-11-22

Fubara, Blessing (Department: 1613)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S078080, C514S509000

Reexamination Certificate

active

08062653

ABSTRACT:
The present invention provides NO and, optionally, drug releasing macromers and oligomers wherein the drug molecule and NO releasing moiety are linked an absorbable macromer or oligomeric chain susceptible to hydrolytic degradation and wherein the macromer or oligomer comprises of repeat units derived from safe and biocompatible molecules such as glycolic acid, lactic acid, caprolactone and p-dioxanone. Furthermore, the present invention relates to controlled release of nitric oxide (NO) and/or drug molecule from a NO and drug releasing macromer or oligomer. Moreover, the present invention also relates to medical devices, medical device coatings and therapeutic formulations comprising of nitric oxide and drug releasing macromers and oligomers of the present invention.

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