Controlled release of miotic and mydriatic drugs in the anterior

Details Controlled release of miotic and mydriatic drugs in the anterior Controlled release of miotic and mydriatic drugs in the anterior

1995-04-18

1997-03-18

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

Ophthalmic preparation

514912, A61K 3174

Patent

active

056120273

ABSTRACT:
The present invention relates to compositions which maintain the structural integrity of the anterior chamber of the eye during ophthalmologic surgery, thereby protecting the tissues that form and line the anterior segment from potential damage and simultaneously providing sustained delivery of a miotic or mydriatic agent. The present invention provides for compositions which comprise a viscoelastic polymer, wherein sustained release of a miotic or mydriatic agent is mediated by ionic interactions, as well as for compositions wherein sustained release of a miotic or mydriatic agent is mediated by microcapsules or copolymer micelles.

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Schoenwald, 1993, "Pharmacokinetics in Ocular Drug Delivery" (chapter 10), Biopharmaceuticals of Ocular Drug Delivery, CRC Press, Inc., Boca Raton, Fl.
Hayakawa et al. 1983, Macromolecules 16:1642.

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