Controlled release of anti-arrhythmic agents

Details Controlled release of anti-arrhythmic agents Controlled release of anti-arrhythmic agents

2006-04-04

2006-04-04

Page, Thurman K. (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C424S400000, C424S422000, C424S425000, C424S488000

Reexamination Certificate

active

07022343

ABSTRACT:
Methods for the simple, reliable application and local controlled release of selected anti-arrhythmia drugs from a hydrogel applied to or polymerized on the tissues of the heart or its vessels, especially in conjunction with cardiac bypass or other cardiac surgery, have been developed. The anti-arrhythmia drugs are incorporated into hydrogels that biodegrade and adhere to the tissues to which the anti-arrhythmic drugs are to be delivered. The hydrogels may be formed in vitro or in vivo. In a preferred embodiment, the drugs are effective to lengthen atrial effective refractory period. A particularly preferred drug is amiodarone.

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