Controlled release morphine preparation

Details Controlled release morphine preparation Controlled release morphine preparation

1995-01-04

1996-05-28

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424464, 424468, A61K 922

Patent

active

055209319

ABSTRACT:
The present invention concerns an oral morphine preparation having essentially complete bioavailability and, for the major part of the dissolution, an essentially zero order and essentially pH independent release of morphine for a period of at least 8 hours, preferably at least 12 hours, during which a period less than 100% is dissolved. In the preparation, the morphine, in the form of an easily soluble salt, is present in a combination with a buffering agent in a preparation coated with a diffusion membrane.

REFERENCES:
patent: 4461598 (1984-07-01), Flechs
patent: 4557925 (1985-12-01), Lindahl et al.
patent: 4970075 (1990-11-01), Oshlack
patent: 4996047 (1991-02-01), Kelleher et al.
patent: 5178868 (1993-01-01), Malmqvist-Grandlund et al.
"The United States Experience with Oral Controlled-Release Morphine (MS Contin Tablets)", Cancer 63:2348-2354, Jun. 1 Supplement 1989, Robert F. Kaiko et al.

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