Controlled release metformin compositions

Details Controlled release metformin compositions Controlled release metformin compositions

2005-03-15

2005-03-15

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C424S457000, C424S474000, C424S480000

Reexamination Certificate

active

06866866

ABSTRACT:
A composition for treating patients having non-insulin-dependent diabetes mellitus (NIDDM) by administering a controlled release oral solid dosage form containing preferably a biguanide drug such as metformin, on a once-a-day basis. The dosage form provides a mean time to maximum plasma concentration (Tmax) of the drug which occurs at 5.5 to 7.5 hours after oral administration on a once-a-day basis to human patients. Preferably, the dose of drug is administered at dinnertime to a patient in the fed state.

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Chiao, C. Sustained-Release Drug Delivery Systems Remington: The Science and Practice of Pharmacy, 1995, Mack Publishing Company, Easton, PA pp. 1660-1669.

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