Controlled-release medical preparations

Details Controlled-release medical preparations Controlled-release medical preparations

1985-09-05

1989-04-25

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

A61K 944, A61K 932, A61K 922

Patent

active

048246786

ABSTRACT:
The present invention concerns a novel pharmaceutical preparation having a biphasic release pattern. The preparation comprises a tablet core containing a drug. The tablet is coated with a coating essentially consisting of a film-forming water-insoluble polymer having fine water soluble particles randomly distributed therein. The fine particles include a drug active substance, which is the same as the drug in the core. The drug active substance in the particles may also be different from the one in the tablet core.

REFERENCES:
patent: 2887438 (1959-05-01), Cooper et al.
patent: 3538214 (1970-11-01), Polli
patent: 4557925 (1985-12-01), Lindahl et al.
patent: 4769027 (1988-09-01), Baker et al.
Goran Kallstrand and Bo Ekman, "Membrane-Coated Tablets: A System for the Controlled Release of Drugs", Journal of Pharmaceutical Sciences, vol. 72, No. 7 (Jul. 1983), pp. 772-775.
L. Bonnet "Process for Making Microporous Membranes", Research Disclosure, vol. 135, pp. 74-75 (Jul. 1975).

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