Controlled release matrix for pharmaceuticals

Details Controlled release matrix for pharmaceuticals Controlled release matrix for pharmaceuticals

1995-10-02

1998-09-22

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424487, 424459, 424468, 427 221, 427212, A61K 916, A61K 958, A61K 922, A61K 4706

Patent

active

058111263

ABSTRACT:
A controlled release pharmaceutical composition for oral administration in humans or animals, comprising a controlled release matrix comprising a pharmaceutically acceptable sodium alginate, a pharmaceutically acceptable water swellable polymer, a pharmaceutically acceptable C.sub.2 -C.sub.50 edible hydrocarbon derivative having a melting point ranging from 25.degree. C. and 90.degree. C. and a pharmaceutically acceptable divalent salt selected from the group consisting of an iron salt, a zinc salt, a magnesium salt, an aluminum salt and a calcium salt and mixtures of any of the foregoing and a therapeutically active agent to be administered and a lubricant or lubricants suitable for forming the composition into tablets or capsules and methods of making and using the same.

REFERENCES:
patent: 3108046 (1963-10-01), Hardit
patent: 4235870 (1980-11-01), Leslie
patent: 4401456 (1983-08-01), Connick, Jr.
patent: 4717713 (1988-01-01), Zatz et al.
patent: 4842866 (1989-06-01), Horder
patent: 4861598 (1989-08-01), Oshlack
patent: 5102666 (1992-04-01), Acharya
patent: 5215768 (1993-06-01), Krishamurthy
patent: 5229128 (1993-07-01), Haddad et al.
patent: 5230901 (1993-07-01), Einig et al.
Abstract of Japanese Patent No. 1-163118 (A), entitled "Multi-Layer Suppository", Granted Jun. 27, 1989.

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