Controlled release liquid dosage formulation

Details Controlled release liquid dosage formulation Controlled release liquid dosage formulation

1986-07-14

1989-10-24

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

426472, A61K 4700

Patent

active

048760943

ABSTRACT:
A liquid dual coated dosage formulation sustained release pharmaceutic having substantial shelf life prior to ingestion is disclosed. A dual coating is applied over controlled release cores to form dosage forms and the coatings comprise fats melting at less than approximately 101.degree. F. overcoated with cellulose acetate phthalate or zein. The dual coated dosage forms are dispersed in a sugar based acidic liquid carrier such as high fructose corn syrup and display a shelf life of up to approximately at least 45 days while still retaining their release profiles following ingestion. Cellulose acetate phthalate coated dosage form cores can in addition be dispersed in aqueous liquids of pH <5.

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patent: 3371015 (1968-02-01), Sjorgren et al.
patent: 4432966 (1984-02-01), Zectoun et al.
patent: 4695467 (1987-09-01), Uemura et al.

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