Controlled release formulations using intelligent polymers

Details Controlled release formulations using intelligent polymers Controlled release formulations using intelligent polymers

2005-05-17

2005-05-17

Spear, James (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C424S469000, C424S470000, C424S482000

Reexamination Certificate

active

06893661

ABSTRACT:
An extended release dosage composition of pharmaceutically active substances that have a water contact angle (θ) such that cos θ is between +0.9848 and −0.9848 presented as a matrix tablet containing the said pharmaceutically active substances, with/without suitable pharmaceutical excipients in intimate mixture with two groups of intelligent polymers having opposing wettability characteristics, one demonstrating a stronger tendency towards hydrophobicity and the other a stronger tendency towards hydrophilicity, the polymer combination being between the ratios of 1:50 and 50:1 amounts effective to control the release of said pharmaceutically active substances in a mathematically predictable manner, wherein the polymer demonstrating a stronger tendency towards hydrophobicity is not less than 5% wt/wt and preferably between 5-70% wt/wt of the final formulation composition. The intelligent polymers being ethylcellulose (EC) as a more strongly hydrophobic and hydroxyethylcellulose (HEC) and/or hydroxypropyl methylcellulose (HPMC) as more strongly hydrophilic (the ratio of HEC to HPMC being between 1:100 and 100:1). The matrix tablet is optionally coated with an enteric coat, 0-5%-15% wt/wt to prevent the initial burst effect seen in such systems and to impart gastrointestinal tract (GIT) “stealth” characteristics especially in the presence of food.

REFERENCES:
patent: 4167558 (1979-09-01), Sheth et al.
patent: 4259314 (1981-03-01), Lowey
patent: 4308251 (1981-12-01), Dunn et al.
patent: 4361545 (1982-11-01), Powell et al.
patent: 4389393 (1983-06-01), Schor et al.
patent: 4525345 (1985-06-01), Dunn et al.
patent: 4556678 (1985-12-01), Hsiao
patent: 4601894 (1986-07-01), Hanna et al.
patent: 4680323 (1987-07-01), Lowey
patent: 4687757 (1987-08-01), Parrott et al.
patent: 4692337 (1987-09-01), Ukigaya et al.
patent: 4695591 (1987-09-01), Hanna et al.
patent: 4756911 (1988-07-01), Drost et al.
patent: 4853249 (1989-08-01), Takashima et al.
patent: 4968509 (1990-11-01), Radebaugh et al.
patent: 4994276 (1991-02-01), Baichwal et al.
patent: 5000962 (1991-03-01), Sangekar et al.
patent: 5073380 (1991-12-01), Babu et al.
patent: 5162117 (1992-11-01), Stupak et al.
patent: 5264446 (1993-11-01), Hegasy et al.
patent: 5417982 (1995-05-01), Modi
patent: 5439687 (1995-08-01), Compassi
patent: 5451409 (1995-09-01), Rencher et al.
patent: 5462747 (1995-10-01), Radebaugh et al.
patent: 5484608 (1996-01-01), Rudnic et al.
patent: 5543154 (1996-08-01), Rork et al.
patent: 6083532 (2000-07-01), Zhang et al.
patent: 0157695 (1985-09-01), None
patent: 0226884 (1987-07-01), None
patent: 0253490 (1988-01-01), None
patent: 0468436 (1992-01-01), None
patent: 03-206039 (1991-09-01), None
Lin et al,European Journal of Pharmaceutics and Biopharmaceutics, 42(3):193-198 (1996).

Affiliated with

Also associated with

Rating

Controlled release formulations using intelligent polymers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Controlled release formulations using intelligent polymers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled release formulations using intelligent polymers will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3456709