Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1980-10-17
1981-12-29
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
424 21, 424 22, 424 39, A61K 922, A61K 930, A61K 952, A61K 956
Patent
active
043082513
ABSTRACT:
An improved tablet formulation is provided comprising an effective amount of an active therapeutic agent, especially an acidic therapeutic agent such as aspirin, a release-controlling agent, and an erosion-promoting agent in relative amounts to provide a criticality factor of less than 450, and in proportions of release-controlling and erosion-promoting agent, respectively, between 0.8-1.6 and 1.0-7.5 weight percent per tablet. The tablets of this invention exhibit zero order release in vitro and closely approximate zero order absorption in vivo. The aspirin tablets of the invention produce minimal epigastric distress and can be administered twice-a-day to provide the desired therapeutic effect. The preferred release-controlling agent is cellulose acetate phthalate and the preferred erosion-promoting agent is corn starch.
REFERENCES:
patent: 2798838 (1957-07-01), Robinson
patent: 2895881 (1959-07-01), Harnada
patent: 2951792 (1960-09-01), Swintosky
patent: 2953497 (1960-09-01), Press
patent: 2993836 (1961-07-01), Nash et al.
patent: 3039933 (1962-06-01), Goldman
patent: 3065143 (1963-11-01), Christenson et al.
patent: 3074852 (1963-01-01), Mayron
patent: 3078216 (1963-02-01), Greif
patent: 3080294 (1963-03-01), Shepard
patent: 3081233 (1963-03-01), Enz
patent: 3108046 (1963-10-01), Harbit
patent: 3147187 (1964-09-01), Playfair
patent: 3322633 (1967-05-01), Simoons
patent: 3328256 (1967-06-01), Gaunt
patent: 3330729 (1967-07-01), Johnson, Jr.
patent: 3336155 (1967-08-01), Rowe
patent: 3344029 (1967-09-01), Berger
patent: 3362880 (1968-01-01), Jeffries
patent: 3362881 (1968-01-01), Eberhardt
patent: 3577514 (1971-05-01), Robinson
patent: 3773920 (1973-11-01), Nokamoto et al.
patent: 3906086 (1975-09-01), Guy et al.
patent: 3965256 (1976-06-01), Leslie
patent: 4012498 (1977-03-01), Kornblum et al.
Dunn James M.
Lampard John F.
Boots Pharmaceuticals, Inc.
Friedman Stanley J.
Hueschen Gordon W.
LandOfFree
Controlled release formulations of orally-active medicaments does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Controlled release formulations of orally-active medicaments, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled release formulations of orally-active medicaments will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1018361