Controlled release formulations containing an active...

Details Controlled release formulations containing an active... Controlled release formulations containing an active...

2007-11-13

2010-12-28

Richter, Johann R (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C424S465000, C424S468000, C424S474000, C424S480000, C514S769000, C514S770000, C514S772000, C514S772300, C514S777000, C514S781000, C514S784000, C514S960000, C514S961000, C514S964000

Reexamination Certificate

active

07858656

ABSTRACT:
A controlled release melatonin tablet having a slow release nucleus of melatonin, hydroxypropyl methylcellulose, a lubricant, a volume excipient and a glidant, wherein 95% of the melatonin is released within 5 hours in an oscillating tray containing gastric/intestinal juice at 37° C. and a fast release cortex coating on said nucleus of melatonin, hydroxypropyl methylcellulose and a volume excipient, wherein at least 95% of the melatonin is released within 10 minutes in an oscillating tray containing gastric/intestinal juice at 37° C.

REFERENCES:
patent: 5879710 (1999-03-01), Bromet
Lee et al., “Controlled release of dual drug-loaded hydroxypropyl methylcellulose matrix tablet using drug-containing polymeric coatings”, International Journal of Pharmaceutics (1999), vol. 188, No. 1, pp. 71-80.
Ex parte Stankov (BPAI, Sep. 20, 2007), pp. 1-11.
Material Safety Data Sheet-Aerosil 200 (1990), pp. 1-3.

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