Controlled-release formulations coated with aqueous dispersions

Details Controlled-release formulations coated with aqueous dispersions Controlled-release formulations coated with aqueous dispersions

1993-06-23

1995-12-05

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424461, 424495, 424408, 424418, 5147721, 514781, 427 216, 42721331, 4273722, 427377, 71 6407, 71 6413, A61K 914, A61K 916, A61K 936, A61K 962

Patent

active

054727120

ABSTRACT:
A stabilized solid controlled release formulation having a coating derived from an aqueous dispersion of a hydrophobic polymer is obtained by overcoating a substrate including an active agent selected from the group consisting of a systemically active therapeutic agent, a locally active therapeutic agent, a disinfecting and sanitizing agent, a cleansing agent, a fragrance agent and a fertilizing agent, with an aqueous dispersion of the plasticized hydrophobic polymer and then curing the coated substrate at a temperature above the glass transition temperature of the plasticized hydrophobic polymer, until a curing endpoint is reached at which the coated substrate provides a stabilized dissolution of the active agent which is unchanged after exposure to accelerated storage conditions, the endpoint being determined by comparing the dissolution profile of the formulation immediately after curing to the dissolution profile of the formulation after exposure to accelerated storage conditions of at least one month at a temperature of 37.degree. C. and at a relative humidity of 80%.

REFERENCES:
patent: 3567650 (1971-03-01), Bakan
patent: 3870790 (1975-03-01), Lowey et al.
patent: 4138475 (1979-02-01), McAinsh et al.
patent: 4377568 (1983-03-01), Chopra
patent: 4385078 (1983-05-01), Onda et al.
patent: 4443497 (1984-04-01), Samejima et al.
patent: 4600645 (1986-07-01), Ghebre-Sellasie et al.
patent: 4756911 (1988-07-01), Drost et al.
patent: 4766012 (1988-08-01), Valenti
patent: 4784858 (1988-11-01), Ventouras
patent: 4786505 (1988-11-01), Lovgren et al.
patent: 4786506 (1988-11-01), Fontanelli
patent: 4795327 (1989-01-01), Gaylord et al.
patent: 4810501 (1989-03-01), Ghebre-Sellasie et al.
patent: 4837004 (1989-06-01), Wu et al.
patent: 4837033 (1989-06-01), Kokubo et al.
patent: 4849229 (1989-07-01), Gaylord et al.
patent: 4853230 (1989-08-01), Lovgren et al.
patent: 4954350 (1990-09-01), Jones et al.
patent: 4983730 (1991-01-01), Domeshek et al.
patent: 5008118 (1991-04-01), Iwanmi et al.
patent: 5009897 (1991-04-01), Brinker et al.
patent: 5042842 (1991-06-01), Edgren et al.
patent: 5047258 (1991-09-01), Belanger et al.
patent: 5064650 (1991-11-01), Lew
patent: 5068110 (1991-11-01), Fawzi et al.
patent: 5077053 (1991-12-01), Kuncewitch et al.
patent: 5084278 (1992-01-01), Mehta
patent: 5085866 (1992-02-01), Cowsar et al.
patent: 5091175 (1992-02-01), Imondi et al.
patent: 5096717 (1992-03-01), Wirth et al.
patent: 5112384 (1992-06-01), Paradissis et al.
patent: 5112621 (1992-05-01), Stevens et al.
patent: 5133974 (1992-07-01), Paradissis et al.
patent: 5158777 (1992-10-01), Abramowitz et al.
patent: 5160742 (1992-11-01), Mazer et al.
patent: 5171580 (1992-12-01), Iamartino et al.
patent: 5178866 (1993-01-01), Wright et al.
patent: 5186937 (1993-02-01), Sparks et al.
patent: 5202128 (1993-04-01), Morella et al.
patent: 5213811 (1983-05-01), Friskee et al.
patent: 5219621 (1993-06-01), Geoghegan et al.
D. L. Munday, A. R. Fassihi, 5th Congr. Int. Tech. Pharm. vol. 2, pp. 55-60 Changes in Drug Release Rate, Effect of Temperature and Relative Humidity on Polymeric Film Coating, 1989, Assoc. Pharm. Galenique Ind., Chatenay Malabry, FR.
J. B. Dressman, C. Jarvis, A. G. Ozturk, B. O. Palsson, and T. A. Wheatley 18th Int. Symposium on Controlled Release Of Bioactive Materials pp. 654-655, "Storage Effects on Release From Phenylpropanolamine HCl Pellets Coated With an Ethylcellulose-based Film", 1991, Amsterdam, Netherlands, Pub. by the Controlled Release Society, Inc.

Affiliated with

Also associated with

Rating

Controlled-release formulations coated with aqueous dispersions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Controlled-release formulations coated with aqueous dispersions , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled-release formulations coated with aqueous dispersions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1372352