Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1994-11-16
1998-03-17
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424457, 424463, 424468, 424474, 424475, 514423, A61K 922, A61K 928, A61K 952
Patent
active
057284024
ABSTRACT:
The invention provides a controlled release pharmaceutical unit dose composition for oral administration which comprises: (a) an internal phase which comprises captopril or a prodrug of captopril in admixture with a hydrogel forming agent; and (b) an external phase which comprises a coating which resists dissolution in the stomach.
REFERENCES:
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patent: 4369172 (1983-01-01), Schor et al.
patent: 4389393 (1983-06-01), Schor et al.
patent: 4704285 (1987-11-01), Alderman
patent: 4756911 (1988-07-01), Drost et al.
patent: 4915954 (1990-04-01), Ayer et al.
Metolose SR Brochure ShinEtsu, USP Hydroxypropyl Methylcellulose (1993).
Tech. Info. for Methoccel, Dow Chemical (1991).
Chen Chih-Ming
Chen Jane Chang
Hahn Elliot
Xie Jainbo
Andrx Pharmaceuticals Inc.
Page Thurman K.
Spear James M.
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