Controlled release formulation for poorly soluble basic drugs

Details Controlled release formulation for poorly soluble basic drugs Controlled release formulation for poorly soluble basic drugs

1995-12-19

1998-01-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424484, 424468, A61K 920

Patent

active

057051909

ABSTRACT:
A controlled release, oral, solid, pharmaceutical composition for a reduced daily dosage regimen is described where the therapeutic ingredient is a poorly soluble basic drug. The formulation comprises the use of a water-soluble alginate salt, a complex salt of alginic acid and an organic carboxylic acid in admixture with the therapeutic drug. A particular embodiment comprising a once a day dosage form for clarithromycin is also described.

REFERENCES:
patent: 4172120 (1979-10-01), Todd et al.
patent: 4289751 (1981-09-01), Windheuser
patent: 4296140 (1981-10-01), Jaquith et al.
patent: 4842866 (1989-06-01), Horder et al.
patent: 5498424 (1996-03-01), Klein

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