Controlled release formulation and method

Details Controlled release formulation and method Controlled release formulation and method

1986-05-27

1988-04-19

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424469, 424470, A61K 922, A61K 926

Patent

active

047388501

ABSTRACT:
In accordance with the present invention, a controlled release formulation is provided from which a drug, selected from the group consisting of angiotensin converting enzyme inhibitors and ascorbic acid, is released at a substantially controlled rate. The controlled release formulation of the invention is comprised of a reactive matrix of from about 5 to about 80 percent by weight of the drug in combination with from about 5 to about 70 percent by weight of poly[(1.fwdarw.4)-2-amino-2-deoxy-.beta.-D-glucose] (also referred to as chitosan herein). Further in accordance with the present invention there is provided a gel-like complex formed of the drug and the chitosan in environments ranging from neutral to acidic.

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patent: 4505890 (1985-03-01), Jain et al.
Sawayanagi et al., "Use of Chitosan for Sustained-Release Preparations of Water-Soluble Drugs", Chem. Pharm. Bull., vol. 30, No. 11, (1982) pp. 4213-4215.
Kawashima et al., "Preparation of a Prolonged Release Tablet of Aspirin with Chitosan", Chem. Pharm. Bull., vol. 33, No. 5, (1985) pp. 2107-2113.
Miyazaki et al., "Sustained Release of Indomethacin from Chitosan Granules", Chem. Pharm. Bull., vol. 33, No. 9, (1985) pp. 3986-3992.

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