Controlled release formulation

Details Controlled release formulation Controlled release formulation

1987-07-28

1988-12-20

Dixon, Jr., William R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424468, 424479, 424480, 424482, 514 54, A61K 930

Patent

active

047924527

ABSTRACT:
A controlled release pharmaceutical formulation is provided which releases a pharmaceutical of a basic character at a controlled rate regardless of the pH of the environment, which formulation includes a basic pharmaceutical, up to about 45% by weight of a pH dependent polymer which is a salt of alginic acid, such as sodium alginate, up to about 35% by weight of a pH-independent hydrocarbon gelling agent having a viscosity of up to about 100,000 centipoises in 2% solution at 20.degree. C., binder and excipients.

REFERENCES:
patent: 4610870 (1986-09-01), Jain et al.
Data Sheet D1571, Alginate Industries Limited, London, "Gel Formation with Alginates".
"In vitro Evaluation of Alginate Gel Systems as Sustained Release Drug Delivery Systems", Stockwell, A. F. et al., Journal of Controlled Release 3 (1986) 167-175.

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