Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1996-02-02
1998-07-21
Zitomer, Fred
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424464, 424468, 424471, 424475, 424482, A61K 932, A61K 920, A61K 930
Patent
active
057832129
ABSTRACT:
The present invention pertains to a controlled release pharmaceutical tablet having at least three layers, two barrier layers and one drug layer. The two barrier layers erode more quickly than the drug layer. All layers are formed from swellable, erodible polymers. The drug layer can have a different composition from the two barrier layers. The three layers can also differ in thickness. The pharmaceutical agent is contained in the drug layer and is released as the tablet layer swells to allow diffusion through the tablet layers, and as the layers erode. The barrier layers are made from swellable erodible polymers which erode away to reveal more of the drug layer, as the tablet dissolves.
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Fassihi Reza
Yang Libo
Temple University--of the Commonwealth System of Higher Educatio
Zitomer Fred
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