Controlled release dressing for enzymatic debridement of...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...

Reexamination Certificate

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Reexamination Certificate

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07368128

ABSTRACT:
A dressing for debridement of necrotic and non-viable tissue in a wound, wherein the dressing comprises an effective amount of one or more proteolytic enzymes incorporated in a degradable polymeric material. The dressing of the invention provides effective debridement of necrotic wounds over a prolonged period of time, as the enzymes may be released over time. As the enzymes are incorporated in the polymeric material, a high stability is achieved.

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Markvicheva E.A. et al., Polymer coatings with immobilized thrombin or peptides: preparation and use for wound healing, Voprosy Meditsinskoi Khimii, 2002, 48(6): 570-576, entire document, with English abstract on p. 576.
Yudanova T.N. et al., Preparation and properties of medical bandage materials with combined action, Khimicheskaya Tekhnologiya (Moscow, Russian Federation), 2002, 12: 30-33, entire document, (provided with a separate English translation, from STN database search).
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