Controlled release dosage forms having a defined water content

Details Controlled release dosage forms having a defined water content Controlled release dosage forms having a defined water content

1991-05-17

1992-02-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424455, 424459, 424468, A61K 952

Patent

active

050911899

ABSTRACT:
A controlled release, solid, oral dosage form containing a 3-alkylxanthine, preferably theophylline, at least one hydrophilic or hydrophobic polymer, at least one wax having a melting point between 25.degree. and 90.degree. C. and between 3% and 10% (by weight) water.
Preferably the dosage form is a tablet and the water content is between 4% and 9% (by weight). The amount of water present in the dosage form determines the rate of release of the 3-alkylxanthine.

REFERENCES:
patent: 3965256 (1976-06-01), Leslie
patent: 4743247 (1988-05-01), Wong
patent: 4753800 (1988-06-01), Mozda
patent: 4844910 (1989-07-01), Leslie et al.

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