Controlled release dihydrocodeine composition

Details Controlled release dihydrocodeine composition Controlled release dihydrocodeine composition

1987-05-19

1989-05-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424457, 424468, 424469, 424484, 424499, 424502, A61K 914

Patent

active

048349844

ABSTRACT:
A solid controlled release, oral dosage form, the dosage form comprising an analgesically effective amount of dihydrocodeine or a salt thereof in a controlled release matrix wherein the dissolution rate in vitro of the dosage form, when measured by the USP Paddle Method at 100 rpm in 900 ml aqueous buffer (pH between 1.6 and 7.2) at 37.degree. C. is between 25% and 60% (by weight) dihydrocodeine released after 1 hour, between 45% and 80% (by weight) dihydrocodeine released after 2 hours, between 60% and 90% (by weight) dihydrocodeine released after 3 hours and between 70% and 100% (by weight) dihydrocodeine released after 4 hours, the in vitro release rate being independent of pH between pH 1.6 and 7.2 and chosen such that the peak plasma level of dihydrocodeine obtained in vivo occurs between 2 and 4 hours after administration of the dosage form.

REFERENCES:
patent: 4629620 (1986-12-01), Lindahl et al.

Affiliated with

Also associated with

Rating

Controlled release dihydrocodeine composition does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Controlled release dihydrocodeine composition, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled release dihydrocodeine composition will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2151310