Controlled release device based on aqueous-organic partitioning

Details Controlled release device based on aqueous-organic partitioning Controlled release device based on aqueous-organic partitioning

1994-03-04

2000-08-29

Levy, Neil S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 424424, 424425, 424426, 424443, 424444, 424447, 424448, 424449, A61K 970

Patent

active

061104817

ABSTRACT:
A novel controlled release device employing microporous membranes with or without a nonporous coating and aqueous-organic partitioning of the bioreactive substances to be delivered is provided. Devices and methods for delivering pharmaceuticals, pest-control substances, hormones, nutrients and fragrances to humans, animals or any environment are also provided.

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patent: 4351337 (1982-09-01), Sidman
patent: 5028435 (1991-07-01), Katz et al.
patent: 5292515 (1994-03-01), Moro et al.
Langer, R., "New Methods of Drug Delivery", Science, 249, 1527-1533, 1990.
Vyavahare et al., "Zero Order Release from Glassy Hydrogels. II Matrix Effects", J. Membrane Sci., 54, 205-220, 1990.
Fischel-Ghodsian et al., "Enzymatically Controlled Drug Delivery", Proc Natl. Acad. Sci. USA, 85, 2403-2406, 1988.
Bhave and Sirkar, "Gas Permeation and Separation with Aqueous Immobilized in Microporous Hydrophobic Hollow Fibers", ACS Symp. Ser. 347, 138-150, 1987.
Reid et al., Properties of Gases and Liquids, McGraw Hill Book Co., New York, 1977 (relevant pages).
Prasad and Sirkar, "Dispersion-Free Solvent Extraction with Microporous Hollow-Fiber Modules", A.I.Ch.E.J., 34(2), 177-188, 1988.

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