Controlled release calcium channel blocker microcapsules

Details Controlled release calcium channel blocker microcapsules Controlled release calcium channel blocker microcapsules

1991-06-25

1993-10-12

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424452, 424461, 424480, 424492, 424495, 42721331, 42721332, 42721333, 42721336, 42840224, 514821, 514963, 514965, A61K 962, A61K 964, B01J 1306

Patent

active

052523373

ABSTRACT:
A controlled release formulation of a calcium channel blocker for oral administration contains non-pareil seeds loaded with a calcium channel blocker, particularly diltiazem, nifedipine, or verapamil, and then microencapsulated in ethylcellulose by phase separation techniques. The resultant microcapsules provide an approximately zero order release rate, preferably over 12 to 16 hours. These microcapsules may be filled into gelatin capsules.

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