Controlled ocular lens regeneration

Surgery – Instruments – Light application

Reexamination Certificate

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C128S898000, C606S004000

Reexamination Certificate

active

06945971

ABSTRACT:
The present invention addresses the treatment of ocular conditions by the enhancement of lens regeneration. This is accomplished by the administration of a high viscosity composition including a hyaluronic acid compound and laser photoablation. Excess high viscosity composition may be removed by focal laser photophacoablation. Additionally, a collagen product may be injected within the lens capsule to improve lens cell proliferation and differentiation, and to improve the configuration, shape and structure of regenerated lenses. Various embodiments involving the enhancement of lens regeneration are described. For example, lens regeneration may be enhanced by filling the lens capsule bag with the inventive hyaluronic acid compound; by inserting at least one collagen patch in the lens capsule; and/or by injecting a collagen-based product into the lens capsule.

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Arlene Gwon, et al., “Focal Laser Photophacoablation of Normal and Cataractous Lenses in Rabbits: Preliminary Report ,” J. of Cataract and Refractive Surgery, 21:282-286, 1995.
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Arlene Gwon, et al., “Restoring Lens Capsule Integrity Enhances Lens Regeneration in New Zealand Albino Rabbits and Cats,” J. Cataract and Refractive Surgery, 19:735-746, 1993.
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Arlene E. Gwon, et al., “Induction of De Novo Synthesis of Crystalline Lenses in Aphakic Rabbits,” Experimental Eye Research, 49: 913-926, 1989.

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