Controlled nucleic acid delivery systems

Details Controlled nucleic acid delivery systems Controlled nucleic acid delivery systems

2006-04-18

2006-04-18

Woitach, Joseph (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S455000, C435S825000, C435S320100, C424S450000

Reexamination Certificate

active

07030097

ABSTRACT:
One aspect of the present invention relates to a nucleic acid delivery system including a polymeric structure formed of a biocompatible polymer and a mixture comprising one or more nucleic acid molecules and a first co-dispersant, the mixture being contained within the polymeric structure, wherein the first co-dispersant is present in an amount effective to control diffusion of the one or more nucleic acid from the polymeric structure. Compositions including the nucleic acid delivery system and a pharmaceutically-acceptable carrier are disclosed. Methods of making the nucleic acid delivery system and their use in delivering nucleic acid into a patient and modifying gene expression in a target cell are also disclosed.

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