Controlled modification of eukaryotic genomes

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses

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4353201, 800205, 935 30, C12N 1500, C12N 1509, C12N 1563, A01H 104

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055276954

ABSTRACT:
DNA constructs are provided for the creation of transgenic eukaryotic cells. These DNA constructs allow a more precise and effective transformation procedure by enabling the targeting of DNA sequences for insertion into a particular DNA locus, while enabling the removal of any randomly inserted DNA sequences that occur as a by product of known transformation procedures.

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