Controlled-intensity multiple-frequency multiple-axis...

Details Controlled-intensity multiple-frequency multiple-axis... Controlled-intensity multiple-frequency multiple-axis...

2007-10-09

2007-10-09

Font, Frank G. (Department: 2883)

Optical waveguides

Optical transmission cable

Tightly confined

C385S111000, C385S901000

Reexamination Certificate

active

10788724

ABSTRACT:
In one embodiment a macroscopically-sized specimen is illuminated with radiations of selectable multiple intensities and frequencies for viewing along a single viewing axis. A stage supports specimen to be observed. First and second illumination sources provide respective first and second radiations at predetermined different colors, permissively of different intensities. A special “bifurcated” fiber optic cable receives the first radiation into a first one of two radiation-receiving, or input, ends, and the second radiation into a second one of two radiation-receiving, or input, ends, so as to produce at each of at least two radiation-emitting, or output, ends an illuminating beam in which the first and the second radiations are mixed. The intensities and colors of both radiations are controllable. The multi-color controlled-intensity radiation beams are particularly useful for excitation of multiple different fluorescent agents, and differently fluorescing regions, within a biological specimen such as, by way of example, a tumorous mouse.

REFERENCES:
patent: 5031078 (1991-07-01), Bornhorst
patent: 5217285 (1993-06-01), Sopori
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patent: 6883952 (2005-04-01), Sander
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patent: 2004/0090671 (2004-05-01), Gilbert
patent: 2005/0211912 (2005-09-01), Fox
patent: 2006/0203244 (2006-09-01), Nilson et al.

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