Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1995-12-07
1999-10-12
Crouch, Deborah
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
4353201, 435 691, 435 698, 514 44, C12N 1563, C12N 1500, A01N 4304, A61K 3170
Patent
active
059654406
ABSTRACT:
An inducible or regulatable retroviral vector for the controlled delivery of a gene product, and in particular, a tetracycline regulated retroviral vector for the controlled delivery of a gene product is disclosed. This retroviral vector contains the following DNA sequences operatively linked from 5' to 3': (a) DNA comprising a first promoter; (b) DNA comprising a second promoter different from the first promoter in (a) and different from the third promoter in (e); (c) DNA encoding a tetracycline regulator unit (tTA) under the transcriptional control of the second promoter; (d) DNA comprising a tetracycline response unit (tetO) in an antisense orientation relative to the DNA encoding the regulator unit of (c); and (e) DNA comprising a third promoter different from the first promoter in (a) and different from the second promoter in (b) wherein the DNA comprising the response unit (d) is comprised within the third promoter.
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Crouch Deborah
Martin Jill D.
The General Hospital Corporation
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