Controlled electroporation and mass transfer across cell...

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Reexamination Certificate

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C435S461000, C435S285200

Reexamination Certificate

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07053063

ABSTRACT:
Electroporation is performed in a controlled manner in individual and multiple biological cells present in biological tissue by monitoring the electrical impedance, defined herein as the ratio of current to voltage in the electroporation cell. The impedance detects the onset of electroporation in the biological cell(s), and this information is used to control the intensity and duration of the voltage to assure that electroporation has occurred without destroying the cell(s). This is applicable to electroporation in general.

REFERENCES:
patent: 4810963 (1989-03-01), Blake-Coleman et al.
patent: 5098843 (1992-03-01), Calvin
patent: 5134070 (1992-07-01), Casnig
patent: 5173158 (1992-12-01), Schmukler
patent: 5283194 (1994-02-01), Schmukler
patent: 5991697 (1999-11-01), Nelson et al.
patent: 6300108 (2001-10-01), Rubinsky et al.
patent: 6482619 (2002-11-01), Rubinsky et al.
patent: 6613211 (2003-09-01), McCormick et al.
patent: WO 01/07583 (2001-02-01), None
Andreason, G.L.,J. Tiss. Cult. Meth., 15:56-62 (1993).
Barber,Advances in Biomedical Engineering, J.E.W. W.Beneken and V. Thevenin (eds) IOS Press pp. 165-173 (1993).
Cook et al.,IEEE Transactions on Biomedical Engineering, 41(6):713-722 (Aug. 1994).
Duraiswami et al.,Engineering and Analysis with Boundary Elements, 22:13-31 (1998).
Duraiswami et al.,Chemical Engineering Science, 32(13):2185-2196 (1997).
Duraiswami et al.,Bounary Element Technology XII, pp. 226-237 (1997).
Fox et al., Sampling Conductivity Images Via MCMC, Mathematics Department, Auckland University, New Zealand (May 1997).
Gencer et al.,IEEE Transactions on Biomedical Engineering, 43(2):139-149 (Feb. 1996).
Gilbert et al.,Biochimica et Biophysica Act, 1334:9-14 (1997).
Griffiths et al.,Phys. Med. Biol., 3(10):1465-1476 (Oct. 1989).
Griffiths et al.,IEEE Transactions on Biomedical Engineering, 42:948-954 (1995).
Griffiths et al.,Phys. Med. Biol., 32(11):1435-1444 (1987).
Glidewell et al.,Biomed Sci Instrum, 29:251-257 (1993).
Gumerov et al.,13th International Conference on Boundary Element Technology, BETECH, Las Vegas, Nevada (Jun. 1999).
Hapala, I.,Critical Reviews in Biotechnology, 17:105-122 (1997).
Heller et al.,Advanced Drug Delivery Reviews, 35:119-129 (1999).
Ho et al.,Critical Reviews in Biotechnology, 16:349-362 (1996).
Holder et al.,Proceedings of the X. International Conference on Electrical Bioimpedance, pp. 479-482 (1997).
Hughes et al.,Physiol. Meas., 15:A199-A209 (1994).
Jaroszeski et al.,Advanced Drug Delivery Reviews, 35:131-137 (1999).
Liu et al.,Clin. Phys. Physiol. Meas., 13(Suppl. A):197-200 (1992).
Lorquin, P.G.,Molecular Biotechnology, 7:5-35 (1997).
Lundqvist et al.,Proc. Natl. Acad. Sci. USA, 95:10356-10360 (1998).
Mir et al.,Cancerology, 313(III):613-618 (1991).
Narayan et al.,J. Urol., 148:1600-1604 (1992).
Neumann et al.,EMBOJ, 7:841-845 (1982).
Schmuckler, “Impedance Spectroscopy of biological cells,”Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers., Proceedings of the 16th Annual Internal Conference of the IEEE.
Sharma et al.,Biophysical Journal, vol. 71:3229-3241 (1996).
Weaver, J.C.,Journal of Cellular Biochemistry, 51:426-435 (1993).
Blad et al., “Impedance spectra of tumour tissue in comparison with normal tissue; a possible clinical application for electrical impedance tomography”Physiol Meas17:A105-A115 (1996).

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