Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1979-05-03
1981-04-14
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
424 22, 424 33, 424 94, 424322, A61K 902, A61K 3117, A61K 3748, A61K 3174
Patent
active
042619696
ABSTRACT:
A novel, closed loop drug delivery system has been developed where the presence or absence of an external compound determines delivery of a drug from a bioerodible polymer. In the described delivery system hydrocortisone is incorporated into a n-hexyl half ester of a methyl vinyl ether-maleic anhydride copolymer and the polymer-drug mixture fabricated into discs. These are then coated with a hydrogel containing immobilized urease. In a medium of constant pH and in the absence of external urea, the release of hydrocortisone is that normally expected for that polymer at the given pH. In the presence of external urea, ammonium bicarbonate and ammonium hydroxide is generated within the hydrogel which accelerates polymer erosion and hence drug release. Drug delivery rate increase is proportional to the amount of external urea and is reversible, that is, when external urea is removed, the rate of drug release gradually returns to its original value.
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Rose Shep K.
World Health Organization
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