Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Reexamination Certificate
2007-01-16
2007-01-16
Tran, S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
C424S490000, C424S499000, C424S501000
Reexamination Certificate
active
10423536
ABSTRACT:
The present invention relates to the molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect. Moreover, the high loading efficiency of hydrophilic drugs can be achieved.
REFERENCES:
patent: 5578325 (1996-11-01), Domb et al.
patent: 6589548 (2003-07-01), Oh et al.
R. Jeyanthi, et al. “Effect of solvent removal technique on the matrix characteristics of polylactide/glycolide microspheres for peptide delivery” Journal of Controlled Release 38 (1996) 235-244.
A. G. Shard, et al. “XPS and SSIMS Analysis Revealing Surface Segregation and Short-Range Order in Solid Films of Block Copolymers of PEO and PLGA” Macromolecules 1997, 30, 3051-3057.
Lee Keon Hyoung
Nam Yoon Sung
Oh Jong Eun
Park Tae Gwan
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