Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-03-07
1997-03-25
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424489, 514951, A61F 202, A61K 916, A61K 950
Patent
active
056142064
ABSTRACT:
This invention relates to the controlled release of calcium sulfate as well as to the controlled release of an additive to a calcium sulfate matrix such as medicaments or pesticides. The controlled release is achieved by a pellet comprising calcium sulfate. The pellet is prepared by the process comprising mixing powder consisting essentially of alpha-calcium sulfate hemihydrate, a solution comprising water, and, optionally, an additive and a powder consisting essentially of beta-calcium sulfate hemihydrate to form a mixture, and forming said mixture into a pellet, wherein said alpha-calcium sulfate hemihydrate and beta-calcium sulfate hemihydrate powders have specified properties such as BET surface areas, densities, mean particle sizes, and purifies. The dissolution rate of the calcium sulfate pellet is controlled by varying the weight ratio of the beta-calcium sulfate hemihydrate powder to the alpha-calcium sulfate hemihydrate powder from 0 to about 3. The invention also provides a method of delivering medicament in vivo by implanting a pellet prepared with medicament into a human or an animal.
REFERENCES:
patent: 3279998 (1964-12-01), Raff et al.
patent: 3632739 (1972-01-01), Kornblum
patent: 4447254 (1984-05-01), Hughes et al.
patent: 4519801 (1985-05-01), Edgren
patent: 4619655 (1986-10-01), Hanker et al.
patent: 4732762 (1988-03-01), Sjogren
patent: 4801458 (1989-01-01), Hidaka et al.
patent: 4853225 (1989-08-01), Wahlig et al.
patent: 4900546 (1990-02-01), Posey-Dowty et al.
patent: 5147403 (1992-09-01), Gitelis
patent: 5149368 (1992-09-01), Liu et al.
patent: 5262166 (1993-11-01), Liu et al.
patent: 5281265 (1994-01-01), Liu
Devine et al., Chemical Abstracts, vol. 112, #25542, 1989.
Devine et al., "Factors Affecting Initial Strength Performance of a Hydroxylapatite-Calcium Sulfate Hemihydrate Composite," Chemical Abstracts, 1988, 112:25542.
S.F. Rosenblum et al -The Effect Of Fibroblast Growth Factor Released From A Calcium Sulfate Carrier On Bone Ingrowth Using A Canine Model -Fourth World Biomaterials Congress, p. 75 -Apr. 24-28, 1992.
Ricci et al. -Stimulation Of Bone Ingrowth Into an Implantable Chamber Through The Use Of Rapidly Resorbing Calcium Sulfate Hemihydrate -Fourth World Biomaterials Congress, p. 49 Apr. 24-28, 1992.
Hernigou et al -Diffusion Of Chemotherapeutic Agents -Rev. Chirurgie Orth. 73: pp. 517-529 (1987) (translation).
Peltier et al -Treatment of Unicameral Bone Cysts By Curettage and Packing with Plaster-of-Paris Pellets -Journal of Bone and Joint Surgery, Incorporated, vol. 60-A, No. 6 -pp. 820-822 6, Sep., 1978.
Mackey et al -Antibiotic-Impregnated Gypsum Pellets In The Surgical Management Of Chronic Osteomyelitis -International Medicine Supplement No. 9, pp. 7-9.
Mackey et al -Antibiotic Loaded Plaster of Paris Pellets -Clinical Orthopaedica and Related Research -No. 167, Jul., 1982 pp. 263-268.
A. Varlet et al -Billes de platre de Paris aux antibiotiques dans le traitment de l'infection osseuse -Revue de Chirurqie Orthopedique, 69, 1983, pp. 239-244 (translation).
Dahners et al -Gentamicin-loaded Plaster of Paris as a Treatment of Experimental Osteomyelitis in Rabbits -Clinical Orthopaedics and Related Research -pp. 278-282 -No. 219 -Jun., 1987.
Devine Timothy R.
Gitelis Steven
Negri Jodi L.
Randolph Donald A.
Azpuru Carlos A.
Wright Medical Technology Inc.
LandOfFree
Controlled dissolution pellet containing calcium sulfate does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Controlled dissolution pellet containing calcium sulfate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled dissolution pellet containing calcium sulfate will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2201180