Controlled dermal penetration enhancement using imidazoles

Details Controlled dermal penetration enhancement using imidazoles Controlled dermal penetration enhancement using imidazoles

1990-05-17

1992-02-11

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514169, 514383, 514396, 514399, 514947, A61K 31595, A61K 3141, A61K 31415

Patent

active

050876201

ABSTRACT:
Topical compositions are described which contain a vehicle which is free of lower alkanols, a pharmacologically active agent whose dermal penetration can be enhanced and a unique penetration control system. The control system contains an imidazole penetration enhancer and either propylene glycol alone or propylene glycol with an isopropyl ester of a fatty acid.

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E.P.O. Application 0270316A2 published Jun. 8, 1988.
S. Bennett et al., "Optimization of Bioavailability of Topical Steroids: Non-occluded Penetration Enhancers under Thermodynamic Control", J. Pharm. Pharmacol. 1985, 37:298-304.

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