Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Arterial prosthesis – Drug delivery
Reexamination Certificate
2005-05-31
2005-05-31
Nguyen, Dave T. (Department: 1632)
Prosthesis (i.e., artificial body members), parts thereof, or ai
Arterial prosthesis
Drug delivery
C514S04400A, C435S320100
Reexamination Certificate
active
06899731
ABSTRACT:
A medical device and method for transportation and release of a therapeutic agent into a mammalian body are disclosed. The medical device is coated with alternating layers of a negatively charged therapeutic agent and a cationic polyelectrolyte, following a controlled adsorption technique. The method is simple, with minimal perturbation to the therapeutic agent and uses clinically acceptable biopolymers such as human serum albumin. The amount of the therapeutic agent that can be delivered by this technique is optimized by the number of the layers of the therapeutic agent adsorbed on the surface of medical device. There is a washing step between alternate layers of the therapeutic agent and cationic polyelectrolyte carrier, so that the amount of the therapeutic agent on the insertable medical device represents the portion that is stably entrapped and adsorbed on to the medical device. The insertable medical device and method according to this invention are capable of reproducibly delivering therapeutic agent to a site in a mammalian body, and allow for a highly reproducible and controllable release kinetics of the therapeutic agent.
REFERENCES:
patent: 5516781 (1996-05-01), Morris et al.
patent: 5578073 (1996-11-01), Haimovich
patent: 5652225 (1997-07-01), Isner
patent: 6004943 (1999-12-01), Shi
patent: 6013780 (2000-01-01), Neufeld
patent: 6099562 (2000-08-01), Ding et al.
patent: 6127448 (2000-10-01), Domb
patent: 6468304 (2002-10-01), Dubois-Rande et al.
patent: 6589546 (2003-07-01), Kamath et al.
patent: 2002/0028243 (2002-03-01), Masters
patent: 0 939 319 (1999-09-01), None
patent: 11-316225 (1999-11-01), None
patent: WO 99/08729 (1999-02-01), None
patent: WO 99/59649 (1999-11-01), None
patent: WO 00/62830 (2000-10-01), None
Anderson et al., Nature, vol. 392, Apr. 25-30, 1998.*
Rosenberg, Science, vol. 287, p. 1751, 2000.*
Verma et al. (Nature, vol. 389, Sep. 18, 1997, pp. 239-242).*
F. Dosio, et al., “Preparation, characterization and properties in vitro and in vivo of a paclitaxel-albumin conjugate”, Journal of Controlled Release, 1997, pp 293-304, vol. 47. (Elsevier Science Publishers B. V. Amsterdam).
Leong Kam W.
Li Weiping
Mao Hai-Quan
Boston Scientific Scimed Inc.
Nguyen Dave T.
LandOfFree
Controlled delivery of therapeutic agents by insertable... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Controlled delivery of therapeutic agents by insertable..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled delivery of therapeutic agents by insertable... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3429892