Controlled delivery of pharmaceuticals from preformed porous pol

Details Controlled delivery of pharmaceuticals from preformed porous pol Controlled delivery of pharmaceuticals from preformed porous pol

1993-02-05

1995-11-28

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424422, 424426, 424493, A61K 952

Patent

active

054705827

ABSTRACT:
A controlled release pharmaceutical composition comprising a physiologically active agent dispersed in preformed porous polymeric microparticles is provided. The active agent concentration may be up to about 10% by weight to achieve controlled release. Each of the porous microparticles has a plurality of preformed pores into which active agent is loaded and from which the active agent is subsequently released to the environment of use. The compositions are capable of delivering physiologically effective amounts of active agent for at least about thirty days, which delivery may be reversibly controlled by exposure to ultrasound.

REFERENCES:
patent: 4389330 (1983-06-01), Tice
patent: 4675189 (1987-06-01), Kent
patent: 4873091 (1989-10-01), Jankower
patent: 4897268 (1990-01-01), Tice
patent: 4917893 (1990-04-01), Okada
patent: 5019400 (1991-05-01), Gombotz
patent: 5100669 (1992-03-01), Hyon

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