Controlled antacid delivery form and method of treatment therewi

Details Controlled antacid delivery form and method of treatment therewi Controlled antacid delivery form and method of treatment therewi

1977-04-29

1979-08-07

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 19, 424127, 424128, 424155, 424156, 424157, 424317, 424319, A61K 924, A61K 922

Patent

active

041637771

ABSTRACT:
A controlled antacid delivery form having an acid neutralizing component in a matrix including a gel-forming, swelling agent and a water insoluble lipid material. These materials are mixed with the antacid component, together with a large amount of sweet excipient, and compressed at high pressure to provide an antacid lozenge which dissolves very slowly in the mouth.
A method for controlled antacid delivery wherein the controlled antacid delivery form is slowly dissolved in the mouth and neutralizes the stomach acid over a long period of time with surprising little antacid, while bathing the esophageal lining with antacid. When the controlled antacid delivery form includes a mixture of antacids having different reactivities towards acid, said method provides for substantially complete utilization of each component.

REFERENCES:
patent: 3555151 (1971-01-01), Kaplan et al.
patent: 3590117 (1971-06-01), Christenson et al.
patent: 3626393 (1971-12-01), Nakamoto et al.
patent: 3641236 (1972-02-01), Coppen et al.
patent: 3773920 (1973-11-01), Nakamoto et al.
patent: 3870790 (1975-03-01), Lowey et al.

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