Controlled alignment of nanobarcodes encoding specific...

Details Controlled alignment of nanobarcodes encoding specific... Controlled alignment of nanobarcodes encoding specific...

2008-04-22

2008-04-22

Lu, Frank (Department: 1634)

Nanotechnology

Nanostructure

Integrated with dissimilar structures on a common substrate

C977S728000, C977S734000, C977S742000, C977S773000, C977S774000, C435S006120, C435S091100, C536S023100, C536S024300, C536S025300

Reexamination Certificate

active

07361821

ABSTRACT:
The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nanobarcodes may be allowed to bind to one or more target molecules. After binding and separation from unbound coded probes, the bound coded probes may be aligned on a surface and analyzed by scanning probe microscopy. The nanobarcodes may be any molecule or complex that is distinguishable by SPM, such as carbon nanotubes, fullerenes, submicrometer metallic barcodes, nanoparticles or quantum dots. Where the probes are oligonucleotides, adjacent coded probes hybridized to a target nucleic acid may be ligated together before alignment and SPM analysis. Compositions comprising coded probes are also disclosed herein. Systems for biomolecule analysis may comprise a scanning probe microscopy (SPM) instrument and at least one coded probe attached to a surface.

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