Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1993-04-12
1995-03-28
Passaniti, Sebastiano
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
128898, A61M 3100
Patent
active
054012430
ABSTRACT:
The activity of chemodenervating agents can be ascertained by injecting locally a known quantity of the agent and determining the extent of inhibition of acetylcholine release about the locus resulting therefrom. Inhibition of acetylcholine release is indicative of denervation in a muscle, therefore the extent of inhibition of acetylcholine release is coextensive with the zone of denervation induced by the quantity of the agent.
REFERENCES:
patent: 2979055 (1961-04-01), de Beer et al.
patent: 3898983 (1975-08-01), Elam
patent: 4331145 (1982-05-01), Winter
patent: 4445515 (1984-05-01), DiResta
patent: 4501582 (1985-02-01), Schulz
patent: 4522302 (1985-06-01), Paikoff
patent: 4664911 (1987-05-01), Uhr et al.
patent: 4810243 (1989-03-01), Howson
patent: 4880014 (1989-11-01), Zarowitz et al.
patent: 4932936 (1990-06-01), Dykstra et al.
patent: 5053005 (1991-10-01), Borodic
patent: 5097834 (1992-03-01), Skrabal
Blitzer, "Botulinum Toxin Injection For The Treatment Of Oromandibular Dystonia", Presented at Meeting of the American Laryngological Association, (1988).
Borodic, "Botulinum A Toxin For The Treatment Of Spasmodic Torticollis: Dysphagia And Regional Toxin Spread", Head & Neck, (1990).
Borodic, "Dose-Response Relationships In Patients Treated With Botulinum Toxin For More Than Three Years", Ear, Nose and Throat, 67:914 (1988).
Borodic, "Blepharospasm And Its Treatment, With Emphasis On The Use Of Botulinum Toxin", Plastic and Reconstructive Surgery, (1989).
Borodic, "Innervation Zone Of Orbicularis Oculi Muscle And Implications For Botulinum A Toxin Therapy", Ophthalmic Plastic and Reconstructive Surgery, 7(1):54-60 (1991).
Das, "Effect of Treatment With Botulinum Toxin On Spasticity", Postgraduate Medical, 65:208-210 (1989).
Das, "Botulinum Toxin In Treating Spasticity", BJCP, 43:401-403.
Dunlop, "Neuroscience Applied To Clinical Problems Botulinum-A Toxin Used For Chemodenervation Of Muscles In Spasm", (Abstract).
Evans, "Botulinum Neurotoxin Type B Its Purification, Radioiodination And Interaction With Rat-Brain Synaptosomal Membranes", Eur. J. Biochem., 154:409-416 (1986).
Gelb, "Controlled Trail Of Botulinum Toxin Injections In The Treatment Of Spasmodic Torticollis", Neurology, 39:80-84 (1989).
Gluckstein, "Clinical Use Of Botulinum Toxin", Current Bibliographies In Medicine, Jan. 1987-Sep. 1990.
Gonnering, "Negative Antibody Response To Long-Term Treatment Of Facial Spasm With Botulinum Toxin", American J of Ophthalmology, 105:313-315 (1988).
Jankovic, "Botulinum A Toxin For Cranial-Cervical Dystonia: A Double-Blind, Placebo-Controlled Study", Neurology, 37:616-623 (1987).
Ludlow, "Spasmodic Dysphonia: Botulinum Toxin Injection After Recurrent Nerve Surgery", Otolaryngol Head Neck Surg, 102:122-131 (1990).
Singh, "Molecular Topography And Secondary Structure Comparisons Of Botulinum Neurotoxin Types A, B And E", Molecular and Cellular Biochemmistry, 86:87-95 (1989).
Snow, "Treatment Of Spasticity With Botulinum Toxin: A Double-Blind Study", Annals Of Neurology, 28:512-515 (1990).
Tsui, "Production Of Circulating Antibodies To Botulinum-A Toxin In Patients Receiving Repeated Injections For Dystonia", (Abstract).
Tsui, "A Pilot Study On The Use of Botulinum Toxin In Spasmodic Torticollis", Can. J. of Neurological Sciences, 12:314-316 (1985).
Tsui, "Local Treatment Of Spasmodic Torticolli With Botulinum Toxin", Can. J. Neurol. Sci., 14:533-535 (1987).
VanZandijcke, "Treatment Of Bruxism With Botulinum Toxin Injections", J. Neurol., Neurosurg., Psychiatry, 53:530 (1990).
Patrinely, "Essential Blepharospasm: A Reivew", Reproduced From Geriatric Ophthalmology, 27-31 (Jul./Aug. 1986).
Engstrom, et al., "Effectiveness of Botulinum Toxin Therapy For Essential Blepharospasm", Ophthalmology, 94:971-975 (1987) (Abstract).
Jankovic, "Botulinum A Toxin in the Treatment of Belpharospasm", Advanced in Neurology, 49:467-472 (1988).
Davidorf, "Treatment of Strabismus with Botulinum", Contemporary Ophthalmic Forum, 5:(6) Nov./Dec. 1987).
Magoon, "The Use of Botulinum Toxin Injection as an Alternative to Strabismus Surgery", Contemporary Ophthalmic Forum, 5:222-229 Nov./Dec. (1987) (Abstract).
Biglan, et al., "Experience with Botulinum A Toxin (Oculinum) in the Treatment of Strabismus", Contemporary Ophthalmic Forum, 5:230-240 (Nov./Dec. (1987).
Duchen, "Changes in Motor Innervation and Cholinesterase Localization Induced by Botulinum Toxin in Skeletal Muscle of the Mouse: Differences Between Fast and Slow Muscles", J. Neurology Neurosurgery and Psychiatry, 33:40-54 (1970).
Duchen, "Histological Differences Between Soleus and Gastrocnemius Muscles in the Mouse After the Local Injection of Botulinum Toxin", (Abstract).
Associated Synapse Biologics
Passaniti Sebastiano
LandOfFree
Controlled administration of chemodenervating pharmaceuticals does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Controlled administration of chemodenervating pharmaceuticals, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled administration of chemodenervating pharmaceuticals will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2247060