Controlled absorption pharmaceutical composition

Details Controlled absorption pharmaceutical composition Controlled absorption pharmaceutical composition

1987-06-19

1989-09-05

Lusigman, Michael

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424471, 424472, A61K 924

Patent

active

048637424

ABSTRACT:
A controlled absorption verapamil containing pellet formulation for oral adminstration comprises a core of a powder mixture containing verapamil or a pharmaceutically acceptable salt thereof and an organic acid and a polymeric material, said core comprising layers of said powder mixture and said polymeric material superimposed one upon the other and said polymeric material being present in an amount effective to ensure that all of said powder mixture is coated into said core and a multi-layer membrane surrounding said core, the number of layers in said membrane and the ratio of the various polymers comprising the membrane being effective to permit release of the verapamil from the pellet at a rate allowing controlled absorption thereof over a 24 hour period following oral administration, said rate being measured in vivo and having a Tmax between 6 and 16 hours.

REFERENCES:
patent: 4461759 (1984-07-01), Dunn
patent: 4606909 (1986-08-01), Bechgaard et al.
Pharmaceutical Composition, Patents Act, 1964, pp. 1-15, BASF Aktiengesellschaft, Fed Rep of German, published 11-3-1982.

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